C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
C07H 19/10 (2006.01) A61K 31/7072 (2006.01) A61K 31/7076 (2006.01) A61K 31/7084 (2006.01) A61P 7/02 (2006.01) C07H 19/20 (2006.01) C07H 19/207 (2006.01)
Patent
CA 2420179
This invention is directed to a method of preventing or treating diseases or conditions associated with platelet aggregation. The method is also directed to a method of treating thrombosis. The method comprises administering to a subject a pharmaceutical composition comprising a therapeutic effective amount of P2Y12 receptor antagonist compound, wherein said amount is effective to bind the P2Y12 receptors on platelets and inhibit ADP-induced platelet aggregation. The P2Y12 receptor antagonist compounds useful for this invention include mononucleoside polyphosphates and dinucleoside polyphosphates of general Formula (I), or salts thereof. The present invention also provides novel compositions comprising mononucleoside polyphosphates and dinucleoside polyphosphates according to Formula (Ia) and (Ib).
L'invention porte sur une méthode de prévention ou de traitement de maladies ou d'états liés à l'agrégation plaquettaire. L'invention porte également sur une méthode de traitement des thromboses consistant à administrer à un sujet une dose à effet thérapeutique d'un composé d'antagoniste des récepteurs du P2Y¿12?, ladite dose fixant lesdits récepteurs sur lesdites plaquettes et inhibant l'agrégation des plaquettes induite par l'ADP. Le composé d'antagoniste des récepteurs du P2Y¿12? de l'invention comporte des mononucléoside polyphosphates et des dinucléoside polyphosphates de formule générale (I), et leurs sels. L'invention porte également sur de nouvelles compositions comportant des mononucléoside polyphosphates et des dinucléoside polyphosphates de formules (Ia) et (Ib).
Boyer Jose L.
Douglass James G.
Olins Gillian M.
Yerxa Benjamin R.
Gowling Lafleur Henderson Llp
Inspire Pharmaceuticals Inc.
University Of North Carolina
LandOfFree
Composition and method for inhibiting platelet aggregation does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Composition and method for inhibiting platelet aggregation, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Composition and method for inhibiting platelet aggregation will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-2033399