A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 33/42 (2006.01) A61K 33/16 (2006.01)
Patent
CA 2057336
IR? 4953 COMPOSITION AND METHOD FOR PREVENTING FLUOROSIS ABSTRACT OF THE DISCLOSURE A fluorosis-free ingestible fluoride ion-containing composition comprising a mixture of pharmaceutically acceptable fluoride and monofluorophosphate in a weight ratio to provide not more than about fifty percent, and preferably not more than about twenty-five percent, of available fluoride ion from the fluoride and the balance from the monofluorophosphate. By "fluorosis-free" composition is meant one which, when ingested, minimizes or obviates the occurrence of fluorosis which ?s a common effect when fluoride is ingested. The composition may contain additional pharmaceutically acceptable adjuvants, such as vitamins, coloring, flavoring, carrie?s, stabilizers, preservatives, medicants and the like, And may be in the form of a powder, tablet, capsule, pill or a liquid in a suitable ingestible carrier. Preferred compounds are alkali metal, ammonium and amine fluorides and monofluorophosphates. Most preferred compounds are sodium fluoride (NaF) and sodium monofluorophosphate (MFP), whose formula is Na2FPO3 and the corresponding potassium salts. The compositions are especially adapted for use as a dietary supplement to provide substantially instantaneous low-dosage fluoride ion from the fluoride compound upon ingestion and a slow, prolonged release of fluoride ion from the monofluorophosphate.
Colgate-Palmolive
Smart & Biggar
LandOfFree
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