C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/47 (2006.01) A61K 38/04 (2006.01)
Patent
CA 2611941
The invention relates to a method for the preparation of a stable, soluble amyloid beta (A.beta.) oligomer and composition thereof for use as an antigen for the generation of antibodies for the treatment of Alzheimer~s disease and other conditions related to abnormal amyloid beta aggregation. The method which uses a pH in excess of 7.0 and high concentrations of A.beta., optionally includes the use of divalent anions or a helix-inducing solvent to form the oligomers. The stable, soluble A.beta. oligomers produced by the method herein have a particle size of 10 to 100 nm in diameter, when measured by a dynamic light scattering technique, and a molecular weight of 100 to 500 kDa.
L'invention porte sur une méthode de préparation d'un oligomère stable et soluble d'amyloïde beta (Aß) et sur ses compositions, utilisés comme antigène produisant des anticorps pour le traitement de la maladie d'Alzheimer, et d'autres états relatifs à l'agrégation anormale de l'Aß. Ladite méthode, qui utilise un pH dépassant 7,0 et une forte concentration d'Aß, consiste facultativement à utiliser des anions divalents ou un solvant inducteur d'hélices pour former les oligomères. Lesdits oligomères ainsi produits présentent un diamètre compris entre 10 et 100 nm (mesuré par diffusion dynamique de lumière) et un poids moléculaire compris entre 100 et 500 kDa.
Evans Robert
Mach Henryk
Nawrocki Denise
Thiriot David
Merck & Co. Inc.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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