A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 48/00 (2006.01) A61K 31/56 (2006.01) A61P 29/00 (2006.01)
Patent
CA 2625969
A method for enhancing the clinical responsiveness to an anti- inflammatory therapy in a patient afflicted with an inflammatory condition, comprising administering an oligonucleotide having the sequence 5' -Xm-CG-Yn-3' in an effective amount to said patient, and wherein X is A, T, C or G; Y is A, T, C or G; m=l-40; n=l-40 and wherein at least one CG dinucleotide is unmethylated. The invention also encompasses the use of such an oligonucleotide for the manufacture of a medicament for enhancing steroid efficacy in the treatment of a patient afflicted with an inflammatory condition.
La présente invention concerne un procédé destiné à améliorer la qualité de la réponse clinique à un traitement anti-inflammatoire chez un patient souffrant d~une pathologie inflammatoire. Ledit procédé comprend l~administration audit patient d~une quantité efficace d~un oligonucléotide présentant la séquence 5' -Xm-CG-Yn-3', où X est A, T, C ou G; Y est A, T, C ou G; m=l-40; n=l-40 et où un ou plusieurs dinucléotides CG sont non méthylés. L~invention concerne également l~utilisation dudit oligonucléotide dans la fabrication d~un médicament destiné à améliorer l~efficacité des stéroïdes dans le traitement d~un patient souffrant d~une pathologie inflammatoire.
Hellstrom Karin
von Stein Oliver
Gowling Lafleur Henderson Llp
Index Pharmaceuticals Ab
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