Composition and method for the treatment and prevention of...

A - Human Necessities – 61 – K

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Details

A61K 39/40 (2006.01) A61K 31/739 (2006.01) A61K 35/74 (2006.01) A61K 39/02 (2006.01) A61P 1/12 (2006.01)

Patent

CA 2517911

The present invention provides a method of treatment or prophylaxis of enteric disease caused by Gram negative bacteria. The method includes the step of administering a vaccine or a hyperimmune material raised against said vaccine to an individual. The vaccine comprises one or more cell wall antigens reactive in a manner characteristic of O group serotypes, or reactive in a manner characteristic of lipopolysaccharide associated antigens, and at least some of said antigens are separated from bacterial cell walls or wall fragments. The invention also provides composition containing hyperimmune material as well as uses of the composition and vaccine.

La présente invention concerne une méthode de traitement ou de prévention d'une maladie entérique causée par une bactérie Gram négative. Cette méthode consiste à administrer un vaccin ou une substance hyperimmune dirigée contre ce vaccin à un individu. Le vaccin comprend un ou plusieurs antigènes de paroi cellulaire réactifs de manière caractéristique aux sérotypes du groupe O, ou réactifs de manière caractéristique aux antigènes associés aux lipopolysaccharides, une partie au moins de ces antigènes étant séparés des parois cellulaires bactériennes ou des fragments de paroi. L'invention concerne également une composition contenant une substance hyperimmune ainsi que des utilisations de cette composition et de ce vaccin.

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