Composition and method for the treatment of senile dementia

Details Composition and method for the treatment of senile dementia Composition and method for the treatment of senile dementia

C - Chemistry, Metallurgy

07

J

C07J 19/00 (2006.01) A61K 31/715 (2006.01) C07J 17/00 (2006.01)

Patent

CA 2046328

ABSTRACT OF THE DISCLOSURE Ginsenosides Rb1 and Rg1 enhance the availability of acetylcholine in the cortical and hippocampal regions of the brain and alleviate the symptoms of Alzheimer-type senile dementia. The Rb1 or Rg1 may be administered together with a metabolic precursor for acetylcholine and/or with a cholinesterase inhibitor. Pure Rb1 is located from a mixture of ginsenosides by a process involving vacuum chromatography on silica gel. Preferably, the mixture of ginsenosides is enriched in Rb1 by partition between an aqueous system and water ethyl acetate- butanol.

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