Composition and method for transdermal delivery of diclofenac

Details Composition and method for transdermal delivery of diclofenac Composition and method for transdermal delivery of diclofenac

A - Human Necessities

61

K

A61K 31/195 (2006.01) A61K 47/00 (2006.01) A61K 47/10 (2006.01) A61K 47/14 (2006.01)

Patent

CA 2112751

COMPOSITION AND METHOD OR TRANSDERMAL DELIVERY OF DICLOFENAC ABSTRACT The topical drug delivery composition and method of the present invention provides a composition and method for delivering amounts of diclofenac effectivefor treating inflamed and/or painful joints or muscles percutaneously via a gel.Diclofenac sodium is solubilized in a mixture of water, a low molecular weight alcohol, and a glycol. In the present invention, the transdermal flux of diclofenac is unexpectedly enhanced by the addition of an ether alcohol and a fatty alcoholester. The transdermal flux can be further enhanced by the addition of a glycol such as hexylene glycol. The effect of different ratios of ethoxydiglycol and C12 15 alcohols benzoate on the transdermal permeation of diclofenac is shown in the figure.

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