Composition and method for treating dry eye syndrome

A - Human Necessities – 61 – K

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A61K 31/355 (2006.01) A61P 27/04 (2006.01)

Patent

CA 2739658

The present invention provides for compositions, medicaments, and methods for treating or alleviating the symptoms of dry eye syndrome or chronic dry eye. More specifically, the present embodiments provide for medicaments consisting of tocopherol or tocotrienol eyedrops, A single topical administration of tocopherol or tocotrienol eyedrops in the eyes of a subject suffering from dry eye alleviates symptoms for at least one day. In particular, the eyedrop medicament consists of .alpha.-tocopheryl acetate; .alpha.-tocopheryl acetate and about 0.5% aqueous component; or .alpha.-tocopheryl acetate, about 2,5% tocopherol emulsifier, and about 20% to about 30% aqueous excipient.

Cette invention concerne des compositions, des médicaments et des méthodes pour traiter ou soulager les symptômes du syndrome de l'il sec ou de l'il sec chronique. Plus spécifiquement, les présents modes de réalisation concernent des médicaments sous forme de gouttes oculaires de tocophérol ou de tocotriénol. Une seule administration topique des gouttes oculaires de tocophérol ou de tocotriénol dans les yeux d'un sujet souffrant de l'il sec soulage les symptômes pendant au moins une journée. En particulier, le médicament sous forme de gouttes oculaires est consititué des éléments suivants : acétate d'a-tocophéryle, acétate d'a-tocophéryle et environ 0,5 % d'un composant aqueux, ou bien acétate d'a-tocophéryle, environ 2,5 % d'émulsifiant du type tocophérol et environ 20-30 % d'excipient aqueux.

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