A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/7052 (2006.01) A01N 1/02 (2006.01) A61K 31/70 (2006.01) A61K 31/7056 (2006.01) A61K 31/7076 (2006.01) A61P 37/06 (2006.01)
Patent
CA 2463105
Compositions and method are provided for prevention and clinical treatment of various forms of graft-versus-host disease (GVHD) by using inhibitors of adenosine deaminase (ADA). In particular, various formulations and dosing regimens of ADA inhibitors such as pentostatin are provided for the treatment of humans in vivo as well as for ex vivo conditioning of organ transplants in order to specifically suppress T-lymphocyte mediated immune responses while minimizing systemic toxicity of the drug.
L'invention concerne des compositions et des procédés pour la prévention et le traitement clinique de différentes formes de réaction du greffon contre l'hôte (GVHD) grâce à des inhibiteurs d'adénosine déaminase (ADA). En particulier, l'invention concerne différentes formulations et schémas posologiques des inhibiteurs ADA tels que la pentostatine conçus pour le traitement d'humains in vivo ainsi que pour le conditionnement de transplantations d'organes afin de supprimer de manière spécifique les réponses immunitaires induites par des lymphocytes T et, en même temps, de réduire la toxicité systémique du médicament.
Dimartino Jorge
Nelson John Tippett
Mayne Pharma (usa) Inc.
Ridout & Maybee Llp
Supergen Inc.
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