Composition and method for treating neurological disorders

Details Composition and method for treating neurological disorders Composition and method for treating neurological disorders

A - Human Necessities

61

K

A61K 31/706 (2006.01) A61K 31/192 (2006.01) A61K 38/15 (2006.01) A61P 25/00 (2006.01)

Patent

CA 2532922

Compositions, kits and methods are provided for treating or preventing neurological disorders associated with aberrant silencing of gene expression by reestablishing the gene expression through inhibition of DNA methylation and/or histone deacetylase. The compositions and methods include administering to a patient suffering from the neurological disorder a therapeutically effective amount of a DNA methylation inhibitor, such as decitabine, preferably in combination with an effective amount of a histone deacetylase inhibitor. The compositions, kits and methods can be used to treat or present neurological disorders such as Lou Gehrig's disease, fragile X syndrome, Parkinson's disease and Alzheimer's disease.

L'invention concerne des compositions, des trousses et des méthodes pour traiter ou pour empêcher des troubles neurologiques associés à un silençage aberrant d'une expression génétique, par le rétablissement de l'expression génétique, au moyen de l'inhibition d'une méthylation d'ADN et/ou d'une déacétylase d'histone. Les compositions et les méthodes de l'invention consistent à administrer à un patient souffrant d'un trouble neurologique, une quantité thérapeutiquement efficace d'un inhibiteur de méthylation d'ADN, notamment la décitabine, de préférence en combinaison avec une quantité efficace d'un inhibiteur de déacétylase d'histone. L'invention concerne des compositions, des trousses et des méthodes pouvant être utilisées pour traiter ou pour éviter des troubles neurologiques, notamment la sclérose latérale amyotrophique, le syndrome de l'X fragile, la maladie de Parkinson et la maladie d'Alzheimer.

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