A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/395 (2006.01) A61K 38/17 (2006.01) C07K 14/705 (2006.01)
Patent
CA 2691784
The present invention provides compositions and methods for the treatment of autoimmune diseases, in particular rheumatoid arthritis. Compounds which function as antagonists of Toll-like Receptor 2 are shown to suppress the immune response which result in the onset and progression of autoimmune disease. In particular monoclonal antibodies which have a binding specificity to Toll-like receptor 2 are disclosed for use in methods for the treatment and/or prophylaxis of autoimmune disease.
La présente invention concerne des compositions et procédés de traitement de maladies auto-immunes, notamment la polyarthrite rhumatoïde. L'invention concerne des composés qui agissent en tant qu'antagonistes du récepteur Toll-like 2 pour supprimer la réponse immunitaire qui est induite par l'apparition et la progression de maladie immunitaire. L'invention concerne en particulier des anticorps monoclonaux qui présentent une liaison spécifique au récepteur Toll-like 2 destinés à être utilisés pour le traitement et/ou la prévention de maladie immunitaire.
Heffernan Mark
Keogh Brian
Locher Christopher
Mcguirk Peter
O'neill Luke
Gowling Lafleur Henderson Llp
Opsona Therapeutics Limited
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