A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/00 (2006.01) A61K 31/47 (2006.01) A61K 38/17 (2006.01) A61P 29/00 (2006.01) A61P 43/00 (2006.01)
Patent
CA 2738605
The invention provides a method for treating or preventing preterm labor in pregnant female subjects. The method comprises the step of administering a therapeutically effective amount of a Toll-like Receptor 9 antagonist sufficient to prevent the activation of Toll-like Receptor 9 by fetal DNA. The invention further provides compositions comprising a Toll-like Receptor 9 antagonist for use in the methods of the invention. Said compositions and methods enhance gestation and therefore improve neonatal morbidity and mortality.
L'invention concerne une méthode destinée à traiter ou à prévenir un accouchement prématuré chez des sujets femelles gestantes. La méthode consiste à administrer une quantité thérapeutiquement efficace d'un antagoniste du récepteur 9 de type Toll, suffisante pour prévenir l'activation du récepteur 9 de type Toll par l'ADN foetal. L'invention concerne de plus des compositions comprenant l'antagoniste du récepteur 9 de type Toll et destinées à être utilisées dans les méthodes de l'invention. Lesdites compositions et méthodes renforcent la gestation et permettent ainsi de réduire la morbidité et la mortalité néonatales.
Daly Sean
O'leary John
O'neill Luke Anthony
Scharfe Nugent Andrea
Gowling Lafleur Henderson Llp
Near Dublin The Provost Fellows And Scholars Of The College Of The Holy And
The Coombe Lying-In Hospital
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