Composition and method for tumor imaging

Details Composition and method for tumor imaging Composition and method for tumor imaging

A - Human Necessities

61

K

A61K 51/04 (2006.01) A61K 49/00 (2006.01) C07B 59/00 (2006.01)

Patent

CA 2220008

A method is provided for enhancing transmembrane transport of a diagnostic agent across a membrane of a living cell. The method comprises contacting a membrane of a living cell with a complex formed between said diagnostic agent and ligands selected from biotin or biotin receptor-binding analogs of biotin, folate or folate receptor-binding analogs of folate, riboflavin or riboflavin receptor-binding analogs of riboflavin to initiate receptor mediated transmembrane transport of the ligand complex. The method is used for imaging tissues in vivo.

Ce procédé permet d'améliorer le transport d'un agent de diagnostic à travers la membrane d'une cellule vivante. Selon ce procédé, on met la membrane d'une cellule vivante en contact avec un complexe constitué de l'agent de diagnostic et de ligands sélectionnés parmi la biotine ou les analogues de biotine se liant aux récepteurs de biotine, le folate ou les analogues de folate se liant aux récepteurs de folate, la riboflavine ou les analogues de riboflavine se liant aux récepteurs de riboflavine, afin d'amorcer le transport transmembranaire du complexe ligand par l'intermédiaire de récepteurs. On utilise ce procédé pour visualiser des tissus in vivo.

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