Composition and method of enhancing electrotransport agent...

A - Human Necessities – 61 – K

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A61K 31/16 (2006.01) A61K 9/00 (2006.01) A61N 1/30 (2006.01)

Patent

CA 2213347

A composition suitable for transdermal electrotransport delivery of an agent through a body surface comprises a free acid/base form of an agent to be delivered by transdermal electrotransport, and a salt form of the agent, and optionally a permeation enhancer. Methods of enhancing transdermal electrotransport delivery and of forming a composition for the enhancement of transdermal electrotransport drug delivery, and a transdermal electrotransport delivery device (10) utilizing the compositions of the invention are disclosed.

La présente invention concerne une composition apte à délivrer par électrotransport percutané un agent à travers la surface du corps, comprenant une forme acide/base libre de l'agent en question, une forme de sel dérivé de ce dernier et, éventuellement, un promoteur de pénétration. L'invention concerne aussi des procédés permettant d'améliorer l'apport par électrotransport percutané, de former une composition améliorant l'apport percutané d'une substance médicamenteuse par électrotransport et un dispositif d'apport par électrotransport percutané (10) mettant en oeuvre les compositions selon l'invention.

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