A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/107 (2006.01) A61K 31/415 (2006.01) A61K 31/4164 (2006.01) A61K 31/7036 (2006.01) A61K 45/06 (2006.01) A61P 31/04 (2006.01) A61P 31/10 (2006.01)
Patent
CA 2635986
A pharmaceutical composition comprises (a) metronidazole in an antibacterially effective amount; and (b) an antifungal agent in an antifungally effective amount, illustratively comprising butoconazole or a pharmaceutically acceptable salt or ester thereof. The composition is adapted for application in a unit dose amount to a vulvovaginal surface and has at least one nonlipoidal internal phase and at least one lipoidal external phase that is bioadhesive to the vulvovaginal surface. The composition is useful for administration to a vulvovaginal surface to treat a mixed bacterial vaginosis and vulvovaginal candidiasis infection.
L'invention concerne une composition pharmaceutique comprenant (a) du métronidazole en dose efficace en termes d'effet antibactérien, et (b) agent antifongique en dose efficace en termes d'effet antifongique, tel que du butoconazole ou un sel ou un ester pharmaceutiquement acceptable de ce composé. Cette composition peut être appliquée en dose unitaire sur une surface vulvo-vaginale et comprend au moins une phase interne non lipidique et au moins une phase externe lipidique qui est bioadhésive sur la surface vulvo-vaginale. Ladite composition peut être administrée par application sur une surface vulvo-vaginale en vue du traitement d'une infection mixte de type vaginose bactérienne et candidose vulvo-vaginale.
Bortz Jonathan
Cuca Robert C.
Kirschner Mitchell
Levinson Saul R.
Drugtech Corporation
Gowling Lafleur Henderson Llp
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