A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 35/12 (2006.01) C12N 5/09 (2010.01) A61K 39/00 (2006.01) A61K 39/385 (2006.01) A61K 39/39 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2339304
The present invention is directed to compositions and methods of treating cancer. The compositions of the present invention include a composition prepared from a tumor cell which is hapten modified and syngeneic to the type of tumor to be treated. The composition has the properties, when administered with an adjuvant to a human suffering from a malignant tumor of the same type as said tumor cell, of eliciting T lymphocytes that infiltrate the tumor of said human, of eliciting an inflammatory immune response against the tumor of said human, and of eliciting a delayed-type hypersensitivity response to the tumor of said human. The methods of the present invention are directed to treating cancer comprising administering a therapeutically effective amount of a composition comprising a tumor cell.
L'invention concerne des compositions et des procédés permettant de traiter le cancer. Ces compositions renferment elles-mêmes une composition élaborée à partir d'une cellule tumorale à modification d'haptène et syngénique par rapport au type de cellule tumorale à traiter. Une fois administrée avec un adjuvant à un patient souffrant d'une tumeur maligne du même type que celui de la cellule tumorale considérée, ladite composition a les propriétés suivantes : activité élicitrice vis-à-vis des lymphocytes T qui infiltrent la tumeur du patient, activité élicitrice vis-à-vis d'une réaction inflammatoire immunitaire contre la tumeur en question, et activité élicitrice vis-à-vis d'une réaction d'hypersensibilité de type différé en liaison avec cette tumeur. L'invention concerne en outre des procédés visant à traiter le cancer, qui consistent à administrer une quantité thérapeutiquement efficace de composition à base de cellule tumorale.
Robic
Thomas Jefferson University
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