Composition and method to prevent graft rejection and other...

A - Human Necessities – 61 – K

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A61K 39/395 (2006.01) A61K 38/17 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C12P 21/08 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2291338

A method is provided for preventing and reversing acute allograft rejection wherein both the CD80/CD86:CD28/CTLA-4 interaction and the CD40:CD154 interaction are interrupted. The effect of the method on treating autoimmune diseases and allergy is also set forth.

On décrit un procédé qui permet de prévenir et inverser une crise de rejet de greffe allogénique pour interrompre tant l'interaction de CD80/CD86 et CD28/CTLA-4 que l'interaction de CD40 et CD154. On décrit en outre le résultat du procédé dans le traitement de maladies ou allergies auto-immunes.

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