A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/21 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2448364
The present invention is directed to compositions and methods for affecting metallocorrinoid uptake. The compositions and methods the present invention are particularly useful in enhancing the up take or availability of biologically active metallocorrinoids (e.g. cobalamin and its analogs). The present inventikon is particularly useful in the treatment or prevention of conditions thatresult from low expression or activity of proteins involved inthe processing of metallocorrinoids, as well as in conditions which would benefit from enhanced uptake or availability of cobalamin okr its biolgically active analogs of cobalamin (e.g. cobalamin drug conjugates).
La présente invention concerne des compositions et des méthodes modifiant l'absorption de métallo-corrinoïdes. Les compositions et les méthodes de la présente invention sont particulièrement utiles pour améliorer l'absorption ou la disponibilité de métallo-corrinoïdes biologiquement actifs (la cobalamine et ses analogues, par exemple). La présente invention est particulièrement utile pour le traitement ou la prévention d'étapes pathologiques résultant d'une faible expression ou activité de protéines impliquées dans la transformation de metallo-corrinoïdes, ainsi que pour les états pathologiques bénéficiant d'une augmentation de l'absorption ou de la disponibilité de la cobalamine ou de ses analogues biologiquement actifs (des conjugués de cobalamine, par exemple).
Bauer Joseph A.
Lindner Daniel J.
Borden Ladner Gervais Llp
The Cleveland Clinic Foundation
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