Composition and methods for modulating cns activity

A - Human Necessities – 61 – K

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A61K 38/17 (2006.01) A61P 25/00 (2006.01) A61P 25/24 (2006.01)

Patent

CA 2547338

The present invention concerns the methods and compositions for treating depression and other behavioral and/or emotional disorders of the central nervous system by administering an agonist of hedgehog signaling. Other disorders amenable to treatment by the subject method include attention deficit hyperactive disorders, non-Alzheimer dementia, and various symptoms of memory loss. The present invention also concerns the methods and compositions for enhancing memory and/or cognitive functions, both in a patient suffering from ailment affecting these functions, and in a subject with no diagnosed deficit in memory or cognitive function. The methods and compositions of the present invention stimulate neurogenesis and differentiation, and enhance synaptic transmission of neurons.

La présente invention a trait à des procédés et des compositions pour le traitement de la dépression et d'autres troubles de comportement et/ou émotionnels du système nerveux central par l'administration d'un agoniste de signalisation Hedgehog. D'autres troubles réagissant au traitement par le procédé de l'invention comprennent des troubles d'hyperactivité avec déficit de l'attention, la démence de type non Alzheimer, et divers symptômes de perte de la mémoire. La présente invention a également trait à des procédés et des compositions pour l'amélioration de la mémoire et/ou des fonctions cognitives, chez un patient atteint d'un trouble affectant ces fonctions ainsi que chez un sujet non diagnostiqué comme atteint de déficit de la mémoire ou de la fonction cognitive. Les procédés et les compositions de la présente invention stimulent la neurogenèse et la différenciation, et améliorent la transmission synaptique des neurones.

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