A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/17 (2006.01) A61K 38/45 (2006.01) C12Q 1/68 (2006.01)
Patent
CA 2264262
The present invention relates to the length of telomeres and to their effect on proliferation and senescence in cells. More precisely, it concerns the ability of hnRNP A1 and its shortened derivative UP1 to alter the length of telomeres in cells. The present invention also relates to methods and compositions that will prevent or activate the conversion of A1 into UP1 by proteolytic cleavage as means of increasing or decreasing the proliferative capacity of cells and to delay or precipitate the onset of senescence. In addition the invention relates to agents which can protect mammalian telomeric repeats and modulate telomere replication. Finally, the present invention relates to the use of an enzyme that modifies hnRNP A1 into a substrate more susceptible to proteolytic cleavage.
Chabot Benoit
Wellinger Raymund
Goudreau Gage Dubuc
Universite de Sherbrooke
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