Composition and methods for monitoring the binding of a1/up1...

Details Composition and methods for monitoring the binding of a1/up1... Composition and methods for monitoring the binding of a1/up1...

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) C12Q 1/48 (2006.01) G01N 33/53 (2006.01) G01N 33/535 (2006.01) G01N 33/573 (2006.01)

Patent

CA 2302134

The present invention relates to the length of telomeres and to their effect on proliferation and senescence in cells. More specifically, it concerns the ability of hnRNP A1 and its shortened derivative UP1 to alter the length of telomeres in cells. More precisely, the invention relates to the ability of A1/UP1 to bind telomerase RNA, to bind and to protect mammalian telomeric DNA, and to modulate telomere extension and replication. Finally, the present invention relates to agents which can interfere with the binding of A1/UP1 to telomeres and telomerase, and to the use of protection, extension and replication assays to measure the biological impact of these agents.

La présente invention a trait à la longueur des télomères et à leurs effets sur la prolifération et la senescence des cellules. Plus précisément, elle concerne la capacité de hnRNP A1 et de son dérivé plus court UP1 à modifier la longueur des télomères des cellules. L'invention porte sur la capacité de l'A1/UP1 à se lier à l'ARN télomèrase, à se lier et à protéger l'ADN télomérique des mammifères, et à réguler l'allongement et la réplication des télomères. Enfin, la présente invention se rapporte aux agents ayant des répercussions sur la liaison de l'A1/UP1 aux télomères et à la télomérase, et à l'utilisation d'essais relatifs à la protection, à l'allongement et à la réplication afin de mesurer les effets biologiques de ces agents.

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