Composition and methods for the detection of cripto-3

Details Composition and methods for the detection of cripto-3 Composition and methods for the detection of cripto-3

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01)

Patent

CA 2650379

The present invention is based, at least in part, on the discovery that the pseudogene TDGF3 (Cripto-3) is expressed in cells and, in particular, that TDGF3 overexpression is associated with transformation of a cell, e.g., TDGF3 is overexpressed in cancer cell lines and cells from tumor tissue. Accordingly, the invention provides compositions, kits, and methods for detecting the presence of a TDGF3 polynucleotide or polypeptide in a sample. The invention further provides compositions, kits and methods for assessing whether a cell is transformed as well as for assessing whether a patient is a suitable candidate for an anti-Cripto antibody therapy.

La présente invention concerne au moins en partie la découverte que le pseudogène TDGF3 (Cripto-3) est exprimé dans des cellules et en particulier que la surexpression du TDGF3 est associée à la transformation d'une cellule, par exemple le TDGF3 est surexprimé dans des lignées cellulaires cancéreuses et dans des cellules provenant d'un tissu tumoral. Par conséquent, l'invention concerne des compositions, des kits et des procédés de détection de la présence d'un polynucléotide ou d'un polypeptide TDGF3 dans un échantillon. L'invention concerne en outre des compositions, des kits et des procédés permettant d'estimer si une cellule est transformée ainsi que d'estimer si un patient est un candidat adéquat pour une thérapie avec des anticorps anti-Cripto.

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