Composition and methods for the generation of bone

A - Human Necessities – 61 – L

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A61L 27/00 (2006.01) A61F 2/28 (2006.01) A61K 6/00 (2006.01) A61K 38/18 (2006.01) A61L 27/36 (2006.01) A61L 27/54 (2006.01) A61L 25/00 (1990.01)

Patent

CA 2103943

ABSTRACT OF THE DISCLOSURE Compositions and methods utilizing TGF-.beta. and demineralized bone matrix are described that are capable of inducing the formation of useful, non-resorptive bone. Bone formation is stimulated by the synergistic activity of a TGF-.beta. molecule, such as TGF-.beta.1 or TGF-5.beta., with a HCI-treated demineralized bone matrix. Normal, hard non-resorptive bone development is stimulated and can be utilized in the treatment of fractures, skeletal defects, surgical repairs and skeletal reconstructions, such as in maxillofacialreconstructions.

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