A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/198 (2006.01) A61K 31/145 (2006.01) A61K 31/706 (2006.01) A61P 35/02 (2006.01)
Patent
CA 2661983
Methods and compositions are provided for treating myelodysplastic syndrome and acute myeloid leukemia, wherein the composition comprises at least one compound according to Formula I: (I) wherein R1 is selected from the group consisting of -NH2, -NH-CH2-CO2H, -NH-CH(CH3)-CO2H, and -NH-C(CH3)2-CO2H, or a pharmaceutically acceptable salt of such a compound; and a DNA methyltransferase inhibitor, or a pharmaceutically acceptable salt thereof.
La présente invention concerne des procédés et compositions permettant de traiter le syndrome myélodysplasique et la leucémie aiguë myéloïde. La composition comprend au moins un composé selon la Formule I : (I) dans laquelle R1 est choisi dans le groupe comprenant -NH2, -NH-CH2-CO2H, -NH-CH(CH3)-CO2H, et -NH-C(CH3)2-CO2H, ou un sel pharmaceutiquement acceptable de ce composé ; et un inhibiteur de l'ADN méthyltransférase, ou un sel pharmaceutiquement acceptable de celui-ci.
Holland James F.
Reddy E. Premkumar
Reddy M. V. Ramana
Silverman Lewis R.
Zinzar Svetlana
Borden Ladner Gervais Llp
Mount Sinai School Of Medicine
Mount Sinai School Of Medicine Of New York University
Temple University - Of The Commonwealth System Of Higher Educati
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