A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/565 (2006.01) A61K 9/70 (2006.01) A61K 31/435 (2006.01) A61K 31/56 (2006.01) A61K 47/10 (2006.01) A61K 47/18 (2006.01)
Patent
CA 2209669
A transdermal penetration-enhancing, drug acid-lability reducing composition and related method are described. Specifically, the transdermal composition comprises: (a) a therapeutically effective amount of a pharmacologically active drug which is subject to acid catalyzed degradation; (b) a pharmaceutically acceptable carrier substantially free of a lower alkanol; and (c) a penetration-enhancing amount of a functional derivative of a fatty acid. Such compositions increase the usefulness of transdermal compositions that rely upon an organic acid such as oleic acid penetration enhancer.
L'invention décrit une composition améliorant la pénétration transdermique et réduisant la labilité d'un médicament sous l'effet d'un acide, ainsi qu'un procédé s'y rapportant. Spécifiquement, ladite composition transdermique comprend: (a) une quantité efficace sur le plan thérapeutique d'un médicament pharmacologiquement actif sujet à une dégradation catalysée par un acide; (b) un excipient pharmaceutiquement acceptable pratiquement exempt d'alcanol inférieur; et (c) une quantité d'un dérivé fonctionnel d'un acide gras améliorant la pénétration. Ces compositions augmentent l'efficacité de compositions transdermiques faisant intervenir un acide organique, telles que les produits améliorant la pénétration à base d'acide oléique.
Noven Pharmaceuticals Inc.
Smart & Biggar
LandOfFree
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