Composition and methods of making and using influenza proteins

Details Composition and methods of making and using influenza proteins Composition and methods of making and using influenza proteins

A - Human Necessities

61

K

A61K 39/145 (2006.01) C07K 14/11 (2006.01)

Patent

CA 2697049

The invention provides compositions of influenza proteins, such as matrix and nucleoprotein, that are presented to an individual's immune system as multimeric displays to induce an immune response. The compositions are optionally associated with any type of immunomodulatory compound (IMC) comprising an immunostimutatory sequences (ISS). The invention further provides compositions of influenza matrix and nucleoproteins that can induce cellular and/or humoral immune response. The invention also provides methods of making and using these compositions, e.g, as a vaccine, for ameliorating symptoms associated with infection with influenza virus or for reducing the risk of infection with influenza virus.

L'invention concerne des compositions de protéines de la grippe, telles qu'une matrice et une nucléoprotéine, qui sont présentées à un système immunitaire d'un individu sous forme d'affichages multimères pour induire une réponse immunitaire. Les compositions sont facultativement associées à tout type de composé immunomodulateur (IMC) comprenant des séquences immunostimulatrices (ISS). L'invention concerne en outre des compositions de matrice et de nucléoprotéines de la grippe qui peuvent induire une réponse immunitaire cellulaire et/ou humorale. L'invention concerne également des procédés de préparation et d'utilisation de ces compositions, par exemple en tant que vaccin, pour améliorer des symptômes associés à une infection par le virus de la grippe ou pour réduire le risque d'infection par le virus de la grippe.

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