Composition and pharmaceutical dosage form for colonic drug...

A - Human Necessities – 61 – K

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A61K 47/36 (2006.01) A61K 9/20 (2006.01) A61K 9/28 (2006.01) A61K 9/48 (2006.01) A61K 9/50 (2006.01) C08L 5/06 (2006.01)

Patent

CA 2336815

A colonic drug delivery composition contains a first polysaccharide and a second polysaccharide wherein both polysaccharides are degradable by colonic enzymes and are mixed at an environmental pH of about 7 or above. A colon selective pharmaceutical composition and dosage form for oral delivery of a drug, nutrient, diagnostic reagent, or mixture thereof includes the drug, nutrient, diagnostic reagent, or mixture thereof in contact with the polysaccharide composition. A method of preparing such a colonic drug delivery composition and the colon selective pharmaceutical composition and dosage form are also disclosed.

Composition servant à administrer un médicament au côlon et contenant un premier polysaccharide et un deuxième polysaccharide, ces deux polysacharrides étant dégradés par les enzymes du côlon et mélangés à un pH égal ou supérieur à 7. Composition pharmaceutique et forme galénique servant à administrer de façon sélective par voie orale au côlon un médicament, une substance nutritive, un réactif de diagnostic ou leur mélange et contenant ces derniers en contact avec la composition de polysaccharides. Procédé servant à préparer la composition d'administration de médicament au côlon et la composition pharmaceutique sélective pour le côlon, ainsi que la forme galénique.

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