Composition and system for iontophoretic transdermal...

A - Human Necessities – 61 – K

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Details

A61K 9/70 (2006.01) A61K 9/00 (2006.01) A61N 1/30 (2006.01)

Patent

CA 2255680

The present invention relates to a pharmaceutical composition for the controlled iontophoretic transdermal delivery of a drug comprising a combination of a drug and an electrically conductive carrier, wherein the administration of the drug to the patient is intended to be enhanced by leading an electrical current from said composition to the patient's skin. According to the invention the electrically conductive carrier is a textile fiber with an ion exchanger group grafted thereto. According to a preferred embodiment the drug is tacrine or its pharmaceutically acceptable salt. The invention further concerns a system for the iontophoretic transdermal delivery of a drug to a patient. In this system, the pharmaceutical composition (22) is attached to the patient's skin and used as one of the poles connected to a source (30) of direct current.

La présente invention concerne une préparation pharmaceutique qui permet l'administration régulière, transdermique, par ionophorèse, d'un médicament. Cette préparation résulte de la combinaison d'un médicament et d'un excipient conducteur d'électricité. Cet excipient est destiné à faciliter l'introduction du médicament dans l'organisme du patient en permettant le passage d'un courant électrique de la préparation en question à la peau du malade. Il consiste en une fibre textile sur laquelle on a greffé un groupe échangeur d'ions. Selon une version préférée de cette invention, le médicament employé est la tacrine ou l'un de ses sels acceptables pour des usages pharmaceutiques. L'invention porte également sur un système servant à l'administration transdermique, par ionophorèse, d'un médicament. Selon ce sytème, la préparation pharmaceutique (22) est fixée sur la peau du patient et constitue l'un des pôles reliés à une source (30) de courant continu.

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