Composition and uses of a retinoid, an anti-irritant...

A - Human Necessities – 61 – K

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Details

A61K 31/12 (2006.01) A61K 8/04 (2006.01) A61K 31/203 (2006.01) A61K 45/06 (2006.01) A61P 17/10 (2006.01) A61Q 5/00 (2006.01) A61Q 19/00 (2006.01)

Patent

CA 2689592

The invention relates to a composition comprising, in a physiologically acceptable medium, at least one retinoid compound chosen from all-trans retinoic acid, isotretinoin, motretinide, and naphthoic acid derivatives of formula (I), and salts and esters thereof : (formula I) where R represents a hydrogen atom, a hydroxyl radical, a branched or nonbranched alkyl radical containing from 1 to 4 carbon atoms, an alkoxy radical containing from 1 to 10 carbon atoms or a cycloaliphatic radical which is substituted or unsubstituted, and at least one anti- irritant compound and benzoyl peroxide. The invention is for use in particular in dermatology.

L'invention concerne une composition comprenant, dans un milieu physiologiquement acceptable, au moins un composé rétinoïde choisi parmi l'acide rétinoïque all-trans, l'isotrétinoïde, la motrétinide et des dérivés d'acide naphtoïque représentés par la formule (I), ainsi que des sels et des esters de ceux-ci. Dans la formule (I), R représente un atome d'hydrogène, un radical hydroxyle, un radical alkyle ramifié ou non ramifié contenant de 1 à 4 atomes de carbone, un radical alcoxy contenant de 1 à 10 atomes de carbone ou un radical cycloaliphatique qui est substitué ou non substitué, et au moins un composé anti-irritant et du peroxyde de benzoyle. La composition est destinée à être utilisée en particulier en dermatologie.

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