Composition and uses of galectin antagonists

Details Composition and uses of galectin antagonists Composition and uses of galectin antagonists

A - Human Necessities

61

K

A61K 31/732 (2006.01) A61K 31/7105 (2006.01) A61K 39/395 (2006.01) A61P 35/00 (2006.01) G01N 33/574 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2521649

The present invention is directed to methods and compositions for augmenting treatment of cancers and other proliferative disorders. In particular embodiments, the invention combines the administration of an agent that inhibits the anti-apoptotic activity of galectin-3 (e.g., a "galectin-3 inhibitor") so as to potentiate the toxicity of a chemotherapeutic agent. In certain preferred embodiments, the conjoint therapies of the present invention can be used to improve the efficacy of those chemotherapeutic agents whose cytotoxicity is influenced by the status of an anti-apoptotic Bcl-2 protein for the treated cell. For instance, galectin-3 inhibitors can be administered in combination with a chemotherapeutic agent that interferes with DNA replication fidelity or cell-cycle progression of cells undergoing unwanted proliferation.

L'invention porte sur des procédés et sur des compositions améliorant le traitement du cancer et autres maladies prolifératives. Dans des exécutions particulières, l'invention associe l'administration d'un agent inhibiteur de l'activité anti-apoptique de la galectine-3 (par exemple "inhibiteur de la galectine-3 ") potentialisant la toxicité d'un agent chimiothérapeutique. Dans certaines exécutions préférées, la thérapie combinée de l'invention peut servir à améliorer l'efficacité de ces agents chimiothérapeutiques dont la cytotoxicité est influencée par l'état de la protéine anti-apoptique Bcl-2 de la cellule traitée. On peut par exemple administrer les inhibiteurs de la galectine-3 en association avec un agent thérapeutique interférant avec la fidélité de réplication de l'ADN ou avec la progression du cycle cellulaire de cellules siège d'une prolifération indésirée.

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