A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/39 (2006.01) A61K 47/00 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2730261
The present invention relates to an immunostimulatory composition comprising a) an adjuvant component, com-prising or consisting of at least one (m)RNA, complexed with a cationic or polycationic compound, and b) at least one free mRNA, encoding at least one therapeutically active protein, antigen, allergen and/or antibody, wherein the immunostimulatory composition is capable to elicit or enhance an innate and optionally an adaptive immune response in a mammal. The inventive im-munostimulatory composition may be a pharmaceutical composition or a vaccine. The invention furthermore relates to a method of preparation of the inventive immunostimulatory composition. The invention also relates to the use of the inventive immunos-timulatory composition or its components (for the preparation of a pharmaceutical composition or a vaccine) for the treatment of various diseases. Finally, the invention relates to kits containing the inventive immunostimulatory composition, its components and/or the pharmaceutical composition or vaccine.
La présente invention concerne une composition immunostimulatrice comprenant a) un composant adjuvant, comprenant ou consistant en au moins un ARN(m), complexé avec un composé cationique ou polycationique, et b) au moins un ARNm libre, codant pour au moins une protéine, un antigène, un allergène et/ou un anticorps thérapeutiquement actifs, la composition immunostimulatrice étant capable de provoquer ou daméliorer une réponse immunitaire innée et éventuellement adaptative chez un mammifère. La composition immunostimulatrice selon linvention peut être une composition pharmaceutique ou un vaccin. Linvention concerne de plus un procédé de préparation de la composition immunostimulatrice selon linvention. Linvention concerne également lutilisation de la composition immunostimulatrice selon linvention ou de ses composants (pour la préparation dune composition pharmaceutique ou dun vaccin) pour le traitement de diverses maladies. Pour finir, l'invention concerne des kits contenant la composition immunostimulatrice selon linvention, ses composants et/ou la composition pharmaceutique ou vaccin.
Fotin-Mleczek Mariola
Voss Soehnke
Curevac Gmbh
Kirby Eades Gale Baker
LandOfFree
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