Composition comprising a katp channel inhibitor for use in...

A - Human Necessities – 61 – K

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A61K 31/64 (2006.01) A61K 31/15 (2006.01) A61K 31/155 (2006.01) A61K 31/235 (2006.01) A61K 31/38 (2006.01) A61K 31/415 (2006.01) A61K 31/4164 (2006.01) A61K 31/44 (2006.01) A61K 31/4402 (2006.01) A61K 31/445 (2006.01) A61K 31/4458 (2006.01) A61K 31/513 (2006.01) A61K 31/54 (2006.01) A61K 31/5415 (2006.01) A61K 45/06 (2006.01)

Patent

CA 2251969

This invention is directed to a pharmacologically acceptable composition for inhibiting or treating hemorrhagic shock in a mammal. The composition includes a KATP inhibitor and a pharmacologically acceptable carrier, with the KATP inhibitor being present in an amount sufficient to inhibit or treat hemorrhagic shock in the mammal. The invention is also directed to a method for inhibiting or treating hemorrhagic shock in a mammal. The method includes administering to the mammal an amount of a KATP channel inhibitor sufficient to inhibit or treat hemorrhagic shock in the mammal. In a preferred form of the invention, the KATP channel inhibitor is selected from the group consisting of sulfonylurea, a guanidine, a phenothiazine, an imidazoline, TMB- 8 (8-N,N-diethylamino)octyl-3,4,5-trimethoxybenzoate, 2,3-butanedione monoxime, disopyramide, gliquidone, chlorpromazine, AMP-NPP, flecainide, MS- 551 and combinations thereof.

Composition acceptable sur le plan pharmacologique pour inhiber ou traiter les chocs hémorragiques chez le mammifère. La composition comprend un inhibiteur de K¿ATP? et un excipient acceptable sur le plan pharmacologique, l'inhibiteur de K¿ATP? étant présent en quantité suffisante pour inhiber ou traiter le choc hémorragique chez le mammifère. L'invention porte également sur une méthode pour inhiber ou traiter les chocs hémorragiques chez le mammifère. Cette méthode comprend l'administration à un mammifère d'une quantité d'inhibiteur de canal K¿ATP? suffisante pour inhiber ou pour traiter un choc hémorragique. Dans sa forme préférée l'inhibiteur de canal K¿ATP? est sélectionnée dans un groupe composé de sulfonylurée, d'une guanidine, d'une phénothizine, d'une imidazoline, de TMB-8 (8-N,N-diéthylamino)octyl-3,4,5-triméthoxybenzoate,2,3-butanedione monoxime, de disopyramide, de gliquidone, de chlorpromazine, d'AMP-NPP, de flécaïnide, de MS-551 et de combinaisons d'éléments de ce groupe.

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