Composition comprising a tramadol material and a selective...

A - Human Necessities – 61 – K

Patent

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Details

A61K 31/421 (2006.01) A61K 31/135 (2006.01) A61K 31/137 (2006.01) A61K 31/365 (2006.01) A61K 31/415 (2006.01) A61K 31/42 (2006.01) A61K 45/06 (2006.01) A61P 19/02 (2006.01) A61P 25/02 (2006.01) A61P 25/04 (2006.01) A61P 25/06 (2006.01) A61P 25/28 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2364127

This invention relates to a pharmaceutical composition comprising a combination of a tramadol material and a selective COX-2 inhibitor drug and use for treating or preventing pain, inflammation and certain neurological disorders and cancers. The compositions have a synergistic effect, use less of each ingredient and have less opioid side effects such as abuse liability, tolerance, constipation and respiratory depression.

L'invention concerne une composition pharmaceutique comprenant une combinaison de tramadol et d'un médicament inhibiteur sélectif de COX-2, ainsi que son utilisation pour le traitement ou la prévention de douleur, d'inflammation et de certains troubles neurologiques et cancers. Les compositions, qui ont un effet de synergie, utilisent une quantité moindre de chaque ingrédient et ont des effets opioïdes secondaires moindres tels que risque de dépendance, tolérance, constipation et dépression respiratoire.

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