Composition comprising amphotericin b methods and systems

Details Composition comprising amphotericin b methods and systems Composition comprising amphotericin b methods and systems

A - Human Necessities

61

K

A61K 9/72 (2006.01) A61K 9/16 (2006.01)

Patent

CA 2567785

A composition includes particles including at least about 95 wt% of amphotericin B, wherein the particles have a mass median diameter ranging from about 1.1 ~m to about 1.9 ~m. Another composition also includes particles including at least about 95 wt% of amphotericin B, wherein at least about 80 wt% of the particles have a geometric diameter ranging from about 1.1 ~m to about 1.9 gm. Yet another composition includes particles including amphotericin B, wherein the particles have a mass median diameter less than about 1.9 ~m, and wherein the amphotericin B has a crystallinity level of at least about 20%. Unit dosage forms, delivery systems, and methods may involve similar compositions.

Cette invention concerne une composition renfermant des particules comprenant au moins environ 95 % en poids d'amphotéricine B, lesquelles particules présentent un diamètre médian massique compris entre environ 1,1 µm et environ 1,9 µm. Une autre composition renferme également des particules comprenant au moins environ 95 % en poids d'amphotéricine B, au moins environ 80 % en poids de ces particules présentant un diamètre géométrique compris entre environ 1,1 µm et environ 1,9 µm. Une autre composition encore renferme des particules comprenant de l'amphotéricine B, lesdites particules présentant un diamètre médian massique inférieur à environ 1,9 µm, l'amphotéricine B présentant un taux de cristallinité d'au moins environ 20 %. Des formes dosifiées unitaires, des systèmes de distribution et des méthodes peuvent comprendre des compositions semblables.

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