Composition comprising calcium ions and at least one...

A - Human Necessities – 01 – N

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A01N 1/02 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2704704

The invention is based on the finding that calcium ions and proteolytic enzymes, particularly papain, act in a synergetic way in the regeneration of skin and connective tissues. Thus, such a combination of active principles can be used for the preparation of culture media for cutaneous and/or connective tissue biopsies, which allow for the maintenance of the biopsies under viable conditions for periods of over 6 months, even for over 3 years, as well as for the preparation of pharmaceutical compositions or medical devices for the treatment of diseases in which the regeneration of cutaneous and connective tissues is beneficial (for instance, injuries and wounds, keloids, paradontopathies, conjunctivitis, nasal and ear polyps, cellulite, human and animal dermatitis), and for the preparation of cosmetic compositions that in particular have an anti-ageing effect on the skin.

L'invention est basée sur la découverte du fait que des ions calcium et des enzymes protéolytiques, en particulier la papaïne, agissent d'une façon synergique dans la régénération de la peau et des tissus conjonctifs. Par conséquent, une telle combinaison de principes actifs peut être utilisée pour la préparation de milieux de culture pour des biopsies de tissus cutanés et/ou conjonctifs, qui permet le maintien des biopsies dans des conditions viables pendant des périodes supérieures à 6 mois, et même supérieures à 3 ans, ainsi que pour la préparation de compositions pharmaceutiques ou de dispositifs médicaux pour le traitement de maladie dans lesquelles la régénération de tissus cutanés et conjonctifs est bénéfique (par exemple, des écorchures et des blessures, des chéloïdes, des paradontopathies, la conjonctivite, des polypes nasaux et auriculaires, la cellulite, des dermatoses humaines et animales), et pour la préparation de compositions cosmétiques qui ont, en particulier, un effet anti-vieillissement sur la peau.

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