Composition comprising il-22 inhibitors and use thereof for...

Details Composition comprising il-22 inhibitors and use thereof for... Composition comprising il-22 inhibitors and use thereof for...

C - Chemistry, Metallurgy

07

K

C07K 16/24 (2006.01) A61K 38/00 (2006.01) A61K 38/20 (2006.01) A61K 39/00 (2006.01) A61K 39/395 (2006.01) A61P 31/00 (2006.01) A61P 37/00 (2006.01) C07K 14/54 (2006.01)

Patent

CA 2438238

Inhibitors of IL-22 are disclosed as well as pharmaceutical compositions and methods of using same. The inhibitors include IL-22 antibodies and are useful for treating inflammatory disorders.

La présente invention concerne des inhibiteurs de IL-22 ainsi que des compositions pharmaceutiques et de procédés mettant en oeuvre lesdits inhibiteurs. Les inhibiteurs comprennent des anticorps de IL-22 et sont utiles pour le traitement des troubles inflammatoires. FIG. 1 : A PROTOCOLE CIA DANS DES SOURIS DBA. MODELE DE SOURIS POUR LE POLYARTHRITE RHUMATOIDE B REGIME PROPHYLACTIQUE F JOUR 0 IMMUNISATION AVEC DU COLLAGENE BOVIN ET L'ADJUVANT DE FREUND INCOMPLETE 21?e¿ JOUR IMMUNISATION AVEC DU COLLAGENE BOVIN ET L'ADJUVANT COMPLET DE FREUND C REACTIF DE TEST : DEBUT 21?e¿ JOUR, 200 µg/SOURIS, 2 FOIS PAR SEMAINE D PREMIERES INDICATIONS DE MALADIE ENVIRON AU 23?e¿ JOUR G REACTIF DE TEST H REGIME THERAPEUTIQUE I ENVIRON AU 40?e¿ JOUR OU APRES

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