Composition comprising non-steroidal anti-inflammatory agent...

Details Composition comprising non-steroidal anti-inflammatory agent... Composition comprising non-steroidal anti-inflammatory agent...

A - Human Necessities

61

K

A61K 31/65 (2006.01)

Patent

CA 2105529

A method for treating mammals suffering from rheumatoid arthritis, other tissue-destructive conditions, and chronic inflammatory or other conditions associated with, excess metalloproteinase activity comprising administering to the mammal an amount of a tetracycline that is effectively anti-metalloproteinase, but that is not effectively antimicrobial, and an amount of a non-steroidal anti- inflammatory agent which, when combined with the effectively anti-metalloproteinase amount of tetracycline, results in a significant reduction of tissue destruction and/or bone loss.

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