Composition comprising non-steroidal non-inflammatory agent...

Details Composition comprising non-steroidal non-inflammatory agent... Composition comprising non-steroidal non-inflammatory agent...

A - Human Necessities

61

K

167/182

A61K 31/65 (2006.01)

Patent

CA 2031368

A method for treating mammals suffering from rheumatoid arthritis and other tissue-destructive (chronic inflammatory or other) conditions associated with excess metalloproteinase activity comprising administering to the mammal an amount of a tetracycline that is effectively anti- metalloproteinase, but that is not effectively antimicrobial, and an amount of non-steroidal anti-inflammatory agent which, when combined with the effectively anti-metalloproteinase amount of tetracycline, results in a significant reduction of tissue destruction and/or bone loss.

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