Composition comprising ocaperidone

Details Composition comprising ocaperidone Composition comprising ocaperidone

A - Human Necessities

61

K

A61K 31/519 (2006.01) A61K 9/36 (2006.01) A61P 25/18 (2006.01)

Patent

CA 2595269

The present invention relates to a composition comprising ocaperidone as an active substance and an effective amount of water-soluble polymers to increase solubility of ocaperidone. The present invention further relates to a therapeutic system for ocaperidone with a compartment for the drug formulation comprising said composition, and to a process for the preparation thereof as well as to the therapeutic use of said composition as antipsychotic drug. The present invention also relates to the solubilisation of ocaperidone in an aqueous medium with the aid of water soluble swellable polymers.

L'invention concerne une composition contenant de l'ocapéridone comme substance active ainsi qu'une quantité efficace de polymères hydrosolubles afin d'augmenter la solubilité de l'ocapéridone. L'invention concerne également un système thérapeutique pour l'ocapéridone pourvu d'un compartiment destiné à la formule médicamenteuse contenant ladite composition, un procédé de préparation de la composition ainsi que l'utilisation thérapeutique de la composition en tant qu'antipsychotique. L'invention concerne enfin la solubilisation de l'ocapéridone dans un milieu aqueux à l'aide de polymères hydrosolubles capables de gonfler.

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