Composition comprising polymeric material and uses thereof

Details Composition comprising polymeric material and uses thereof Composition comprising polymeric material and uses thereof

A - Human Necessities

61

K

A61K 47/36 (2006.01)

Patent

CA 2547843

Compositions for the selective delivery of an agent comprising an uncrosslinked starch modified by an acidic group and an agent are described. The compositions are substantially resistant to degradation and thus result in no or substantially no release of the agent in a first environment, and are capable of degradation in a second environment thereby allowing release of the agent. The pKa of the acidic group of the uncrosslinked starch used is higher than the pH of the first environment and lower than or equal to the pH of the subsequent environment. Also described herein are methods of preparing the compositions, methods of using the compositions and the uncrosslinked starch modified by an acidic group, and corresponding commercial packages.

L'invention concerne des compositions permettant la libération sélective d'un agent contenant un amidon non réticulé, modifié par un groupe acide, et un agent. Les compositions selon l'invention sont sensiblement résistantes à la dégradation, c'est-à-dire qu'elles ne libèrent pas, ou sensiblement pas, ledit agent dans un premier environnement, mais qu'elles se dégradent dans un deuxième environnement, libérant ainsi l'agent. Le pKa du groupe acide de l'amidon réticulé utilisé est supérieur au pH du premier environnement et inférieur ou égal au pH du deuxième environnement. L'invention concerne également des procédés de préparation desdites compositions, des procédés d'utilisation de ces compositions et de l'amidon non réticulé modifié par un groupe acide, ainsi que des emballages commerciaux correspondants.

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