C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 9/52 (2006.01) C12N 5/06 (2006.01) C12N 5/08 (2006.01) C12N 9/50 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2193354
Proteolytic enzyme compositions and processes for isolating hepatocytes and pancreatic islet cells from tissue containing them are provided. The enzyme compositions include collagenase, which is essentially free of toxins and non- collagen specific components, and chymopapain, which is essentially free of toxins. The enzyme compositions preferably contain an aqueous mixture of collagenase having an activity of about 25 nkat/ml to about 120 nkat/ml, and chymopapain having an activity of about 0.15 nkat/ml to about 0.55 nkat/ml.
L'invention concerne des compositions d'enzyme protéolytique et des procédés permettant d'isoler des hépatocytes et des cellules d'îlots pancréatiques dans des tissus les contenant. Ces compositions enzymatiques renferment de la collagénase, laquelle est pratiquement dépourvue de toxines et de constituants spécifiques non collagéniques, et de la chymopapaïne, laquelle est pratiquement dépourvue de toxines. Ces compositions enzymatiques contiennent de préférence un mélange aqueux de collagénase présentant une activité de 25 nkat/ml à environ 120 nkat/ml, et de la chymopapaïne présentant une activité d'environ 0,15 nkat/ml à environ 0,55 nkat/ml.
Dinh Tan Thanh
Lee Catherine
Zerfass Cynthia
Baxter International Inc.
Sim & Mcburney
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