Composition containing glycerol trinitrate, method for...

A - Human Necessities – 61 – K

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A61K 9/70 (2006.01) A61K 31/21 (2006.01) A61P 9/10 (2006.01)

Patent

CA 2336704

The invention relates to a preparation for the transdermal, therapeutic introduction of glycerol trinitrate into an organism, through human skin. A therapeutically effective proportion of the active agent is contained in a polyacrylate-based self-adhesive layer and a rear layer which is impermeable to the active agent is provided. The invention is characterised in that a polyacrylate-based self-adhesive substance is used for the layer containing the active agent, in that the concentration of vinyl acetate in this substance is 6 wt.% maximum, and in that the concentration of the active agent in the substance is 25 wt.% maximum.

Préparation pour application thérapeutique transdermique de trinitrate de glycérine, à travers la peau humaine, dans un organisme, renfermant, dans une couche auto-adhésive à base de polyacrylate, avec couche arrière imperméable à la substance active, une fraction thérapeutiquement efficace de la substance active, caractérisée en ce qu'il est prévu d'intercaler dans la couche renfermant la substance active, une matière auto-adhésive à base de polyacrylate, en ce que la concentration d'acétate de vinyle dans ladite matière est au maximum de 6 % en poids, et la concentration de la substance active dans ladite matière est au maximum de 25 % en poids.

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