A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/7105 (2006.01) A61K 31/7088 (2006.01) A61P 35/00 (2006.01) A61K 48/00 (2006.01)
Patent
CA 2690828
Disclosed is a radiation sensitivity-enhancing composition in which a microRNA-21 inhibitor acts as an active ingredient. The microRNA-21 inhibitor is an antisense nucleic acid molecule binding complementarily to microRNA-21. The composition can be administered to a patient in conjunction with irradiation. The inhibitor can act as a radiosensitizer, enhancing the therapeutic effect of such irradiation on cancer high in microRNA-21 expression level, particularly, glioma.
La présente invention concerne une composition amplifiant la sensibilité aux radiations dans laquelle un inhibiteur du microARN-21 agit en tant que principe actif. L'inhibiteur du microARN-21 est une molécule d'acide nucléique antisens se liant de manière complémentaire au microARN-21. La composition peut être administrée à un patient conjointement avec des radiations. L'inhibiteur peut agir en tant que radiosensibilisateur, amplifiant l'effet thérapeutique de telles radiations sur un cancer riche en taux d'expression de microARN-21, particulièrement, un gliome.
Kim Hea Jin
Kim Tae Hoon
Kwak Hee Jin
Lee Donghee
Lee Seung Hoon
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
National Cancer Center
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