Composition containing propargylamine for enhancing cancer...

A - Human Necessities – 61 – K

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A61K 33/24 (2006.01) A61K 31/13 (2006.01) A61K 31/505 (2006.01) A61K 31/675 (2006.01) A61K 31/70 (2006.01) A61K 45/06 (2006.01)

Patent

CA 2318693

Antineoplastic drug modulators are described. The specific modulators referred to are propargylamines which can enhance the cytotoxic effects of antineoplastic drugs on cancer cells while protecting normal cells from damage. The propargylamine modulators can be used to increase the selectivity and effectiveness of conventional antineoplastic drugs, to reduce the unwanted side-effects of cancer chemotherapy, to improve effectiveness of cancer chemotherapy, to improve treatment of cancers for which treatment is otherwise ineffective, to improve therapy of cancers otherwise unresponsive or poorly responsive due to drug-resistance and/or toxicity limited treatment regimens and to render effective chemotherapy for previously untreatable cancers.

L'invention concerne des modulateurs des médicaments antinéoplasiques. Ces modulateurs sont des propargylamines capables d'accroître les effets cytotoxiques des médicaments antinéoplasiques sur les cellules cancéreuses, tout en protégeant les cellules normales. Ils peuvent être utilisés pour augmenter la sélectivité et l'efficacité des médicaments antinéoplasiques classiques, diminuer les effets secondaires indésirables de la chimiothérapie, augmenter l'efficacité de la chimiothérapie, améliorer le traitement des cancers pour lesquels le traitement n'est pas efficace, améliorer le traitement des cancers qui ne répondent pas ou peu au traitement, du fait d'une résistance médicamenteuse et/ou de schémas thérapeutiques limités par leur toxicité, et rendre la chimiothérapie efficace dans les cancers auparavant inaccessibles à un traitement.

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