G - Physics – 01 – N
Patent
G - Physics
01
N
150/14, 150/26,
G01N 33/52 (2006.01) C12Q 1/28 (2006.01) G01N 33/72 (2006.01) G01N 33/84 (2006.01)
Patent
CA 2025803
IMPROVED COMPOSITION, DEVICE AND METHOD OF ASSAYING FOR PEROXIDATIVELY ACTIVE SUBSTANCES Abstract of the Disclosure A new and improved test device and method of determining the presence or concentra- tion of a peroxidatively active substance, such as hemoglobin, in a test sample are disclosed. The test device includes a test pad comprising a suitable carrier matrix incorporating an indicator reagent composition capable of interacting with a peroxidatively active substance to produce a detectable or measurable response. In addition, a new and improved indicator reagent composition, comprising an indicator dye, such as a redox indicator, like a benzidine indicator; a hydro- peroxide; a metal ion complex; and a phosphorus compound having the general structural formula Image or Image , wherein R1 or R2 is selected from the group con- sisting of hydrogen, an unsubstituted or a sub- stituted alkyl moiety including from one to about twelve carbon atoms, an unsubstituted or a sub- stituted aromatic moiety and a residue of an aliphatic or an aromatic polyhydric compound; and wherein X is O, S or NH; such as glyceryl-2- phosphate or phenyl dihydrogen phosphate, is incorporated into a carrier matrix, or used in a wet phase assay, to provide a more accurate and trustworthy assay of a test sample for a peroxi- datively active substance. The improved method and composition are especially useful in the assay of urine for occult blood. MS-1597
Miles Inc.
Osler Hoskin & Harcourt Llp
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