G - Physics – 01 – N
Patent
G - Physics
01
N
150/14, 150/26,
G01N 33/52 (2006.01) C12Q 1/28 (2006.01) G01N 33/72 (2006.01) G01N 33/84 (2006.01)
Patent
CA 2025802
COMPOSITION, DEVICE AND METHOD OF ASSAYING FOR A PEROXIDATIVELY ACTIVE SUBSTANCE Abstract of the Disclosure A new and improved test device and method of determining the presence or concentration of a peroxidatively active substance, such as hemoglobin, in a test sample are disclosed. The test device includes a test pad comprising a suitable carrier matrix incorporating an indicator reagent composition capable of interacting with a peroxidatively active substance to produce a detectable or measurable response. In addition, a new and improved indicator reagent composition, comprising an indicator dye, such as a redox indicator, like a benzidine indicator; a hydroperoxide; an amine borate compound having the general structural formula: Image or Image wherein R1, R2, and R3 are, independently, methyl groups or ethyl groups, and m, n and p are numerals ranging from one to about three; and a buffer, is incorporated into a suitable carrier matrix to provide a more accurate and trustworthy assay of a test sample for a peroxidatively active substance. The improved method and composition are especially useful in the assay of urine for occult blood. MS-1603
Albarella James P.
Pugia Michael J.
Miles Inc.
Osler Hoskin & Harcourt Llp
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