Composition exhibiting enhanced formulation stability and...

A - Human Necessities – 61 – K

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Details

A61K 9/00 (2006.01) A61K 8/11 (2006.01) A61K 8/25 (2006.01) A61K 8/37 (2006.01) A61K 8/38 (2006.01) A61K 8/60 (2006.01) A61K 8/67 (2006.01) A61Q 5/00 (2006.01) A61Q 11/00 (2006.01) A61Q 17/04 (2006.01) A61Q 19/00 (2006.01) A61K 9/50 (2006.01) A61K 9/51 (2006.01)

Patent

CA 2406008

A therapeutic or cosmetic composition for topical application, capable of stabilizing an active ingredient and deliv-ering said ingredient, comprising a plurality of microcapsules having a core-shell structure. The microcapsules have a diameter of approximately 0.1 to 100 microns. The core of each microcapsule includes at least one active ingredient, and is encapsulated within a microcapsular shell, The shell is comprised of at least one inorganic polymer obtained by a sol-gel process, and the shell protects the active ingredient before topical application and releases the ingredient after topical application. This composition is useful to encapsulate active ingredients that are unstable in formulation, or are irritating to the skin. The present invention further discloses a process for the encapsulation of an active ingredient in the form of a dispersion within a hydrophobic phase.

L'invention concerne une composition thérapeutique ou cosmétique destinée à une application topique, ladite composition pouvant stabiliser un ingrédient actif ou administrer ledit ingrédient et renfermant plusieurs microcapsules dotées d'une structure à enveloppe et à noyau. Les microcapsules ont un diamètre compris entre 0,1 et 100 microns. Le noyau de chaque microcapsule comprend au moins un ingrédient actif, et est enrobé par une enveloppe microcapsulaire, cette dernière renfermant au moins un polymère inorganique obtenu par un procédé sol-gel, protégeant l'ingrédient actif avant l'application topique et libérant l'ingrédient après ladite application. On utilise cette composition pour enrober des ingrédients actifs qui ne sont pas stables dans le préparation ou qui irritent la peau. Ladite invention concerne également un procédé d'enrobage d'un ingrédient actif sous forme d'une dispersion au cours d'une phase hydrophobe.

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