A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/395 (2006.01) A61K 31/496 (2006.01) A61P 25/00 (2006.01)
Patent
CA 2514125
The application provides for methods and compositions for inhibiting demyelination, promoting remyelination and/or treating paralysis in a subject in need thereof. Preferably, such compositions include immunoglobulins (e.g., antibodies, antibody fragments, and recombinantly produced antibodies or fragments), polypeptides (e.g., soluble forms of the ligand proteins for integrins) and small molecules, which when administered in an effective amount inhibits demyelination and/or promotes remyelination in a patient. The compositions and methods described herein can also utilize other anti- inflammatory agents used to palliate conditions and diseases associated with demyelination.
L'invention concerne des procédés et des méthodes permettant d'inhiber la démyélinisation, de promouvoir la remyélinisation et/ou de traiter une paralysie chez un sujet ayant besoin de ce traitement. Lesdites compositions comprennent, de préférence, des immunoglobulines (par exemple, des anticorps, des fragments d'anticorps et des anticorps ou des fragments produits par recombinaison), des polypeptides (par exemple, des formes solubles de protéines de ligand d'intégrine) et de petites molécules, qui lorsqu'on les administre en quantité efficace inhibent la démyélinisation et/ou promeuvent la remyélinisation chez un patient. Les compositions et les méthodes décrites peuvent également utiliser d'autres agents anti-inflammatoires pour pallier à des états et à des maladies associés à la démyélinisation.
Dressen Daren
Freedman Stephen
Grant Francine S.
Karlik Steve J.
Konradi Andrei W.
Barrigar Intellectual Property Law
Elan Pharmaceuticals Inc.
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