Composition for controlled release of polypeptides

Details Composition for controlled release of polypeptides Composition for controlled release of polypeptides

A - Human Necessities

61

K

A61K 38/27 (2006.01) A61K 9/00 (2006.01) A61K 47/10 (2006.01)

Patent

CA 2005226

37-21 (10208)A COMPOSITION FOR CONTROLLED RELEASE OF POLYPEPTIDES ABSTRACT Stable somatotropin compositions are provided that are suitable for long term administra- tion of somatotropin by infusion devices. The compo- sition contains at least about 10% bioactive somato- tropin, an effective amount of a stabilizing polyol and a buffer to achieve a pH at which bioactivity is retained over time, such as a pH range from about 4.5 to either about 7 or the isoelectric point of the somatotropin, whichever is greater.

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