Composition for enhanced uptake of polar drugs from mucosal...

Details Composition for enhanced uptake of polar drugs from mucosal... Composition for enhanced uptake of polar drugs from mucosal...

A - Human Necessities

61

K

A61K 47/28 (2006.01) A61K 31/00 (2006.01) A61K 31/70 (2006.01) A61K 31/715 (2006.01) A61K 38/00 (2006.01) A61K 38/08 (2006.01) A61K 45/06 (2006.01) A61K 47/48 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2257563

A composition for administration to a mucosal surface of a mammal comprising a non-metabolisable bile salt analogue and a therapeutic agent. Preferably the non-metabolisable bile salt analogue is a non-naturally occurring conjugate of cholic acid and an amino acid, and in particular cholylsarcosine. Preferably the therapeutic agent is a polar molecule.

L'invention concerne une composition à administrer sur la muqueuse d'un mammifère, comprenant un analogue de sel biliaire non métabolisable et un agent thérapeutique. L'analogue de sel biliaire non métabolisable est de préférence un conjugué d'origine artificielle d'acide cholique et d'un acide aminé, en particulier de la cholysarcosine. L'agent thérapeutique est de préférence une molécule polaire.

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